Dr. Sonya MacParland, PhD, is a University Health Network Scientist in the Toronto General Hospital’s Soham & Shaila Ajmera Family Transplant Centre and an Assistant Professor in the University of Toronto’s department of Laboratory Medicine and Pathobiology and the department of Immunology. Dr. MacParland trained with Dr. Thomas Michalak (Memorial University of Newfoundland) and Dr. Mario Ostrowski (University of Toronto) as part of the CanHepC program.
Dr. MacParland's research program is focused on translating fundamental knowledge about the immune biology of the liver into clinical applications. Dr. MacParland and her research team are using advanced genomics including single cell RNA sequencing to describe the microenvironment of the healthy and diseased human liver. Her team recently developed the first transcriptomic map of the human liver (Nature Communications; 2018) as a platform to examine how immune dysregulation drives liver diseases. Her team is also examining how the liver immune environment can be therapeutically targeted and manipulated using nanoparticles to slow or reverse ongoing damage (Nature Materials; 2016, ACS Nano; 2017).