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Out of public health concerns and given the current travel restrictions and lab closures worldwide because of COVID-19, the 27th International Symposium on Hepatitis C Virus and Related Viruses (HCV2020), scheduled to take place July 6 – 9, 2020 in Montreal, Canada has been postponed to July 6 - 9, 2021 and will now be delivered Virtually.

HCV2021 Program


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All times are in Eastern Daylight Time (EDT) / (GMT - 4:00)

*Program & Topics/Titles are Subject to Change 

Wednesday, July 7, 2021

  • 10:00 12:00

    Session 4: Animal Models, Organoids and Replication Systems

    Co-chairs: Alexander Ploss & Mohsan Saeed

    10:00 - 10:30 | Keynote Lecture 4: Hepaciviruses (In vitro Models)
                               Troels Kasper Høyer Scheel - University of Copenhagen, Copenhagen, Denmark

    10:30 - 11:00 | Keynote Lecture 5: Hepaciviruses (In vivo Models)
                               Amit Kapoor - Nationwide Children's, Columbus, OH, USA

    11:00 - 12:00 | Oral Presentations selected from Abstracts  

    11:00 - 11:15 | Neutralization and receptor usage of cell culture derived rat hepacivirus as a model for hepatitis C
                               Raphael Wolfisberg, University of Copenhagen, Denmark

    11:15 - 11:30 | Functional and structural studies of the glycoprotein E2 of a novel rodent hepacivirus
                               Felicia Schlotthauer, Burnet Institute, Australia

    11:30 - 11:45 | Pathogenesis, miR-122 gene-regulation, and protective immune responses after acute equine hepacivirus infection
                               Joy Ellen Tomlinson, Cornell University College of Veterinary Medicine, United States

    11:45 - 12:00 | Generation and characterization of genetically and antigenically diverse infectious clones of dengue virus serotypes 1-4
                               Tomokazu Tamura, Princeton University, United States

  • 12:00 12:30


  • 12:30 14:20

    Session 5: Innate Immunity/Virus‑Host Interaction

    Co-chairs: Holly Ramage & Takeshi Saito

    12:30 - 13:00 | Plenary Lecture 4: Antibody-mediated Cross-Protection against Tick-transmitted Flaviviruses
                               Michael Diamond -
    Washington University, St. Louis, MO, USA

    13:00 - 13:30 | Keynote Lecture 6: Mitochondrial manipulations by Flaviviridae
                               Laurent Chatel-Chaix -
    National Institute of Scientific Research, Laval, QC, Canada

    13:30 - 14:15 | Oral Presentations selected from Abstracts  

    13:30 - 13:45 | New Insights into the Role of LARP1 in Hepatitis C Virus-infected Cells
                               Hanna Bley, Philipps University of Marburg, Germany

    13:45 - 14:00 | Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) associates with Zika virus RNA and regulates viral replication/life cycle
                               Clement Mazeaud, INRS Centre Armand-Frappier Santé Biotechnologie, Canada

    14:00 - 14:15 | Harnessing IRF1-mediated antiviral immunity to inhibit replication of HCV and other positive-sense RNA viruses
                               Che C. Colpitts, Queen's University, Canada

    14:15 - 14:20 | Introduction to Poster Tours
                               Joyce Wilson

  • 14:20 14:45


  • 14:45 16:45

    Poster Session I : Liver Inflammation, Viral Pathogenesis and Carcinogenesis, Animal models, Innate immunity, Tools

    14:45 -15:30 | Poster Tour A: Liver Inflammation, Viral Pathogenesis and Carcinogenesis
    Co-chairs: Cliona O'Farrelly & Rod Russell

    Hepatitis C Virus Infection Promotes the Lysosomal Degradation of Diacylglycerol O-acyltransferase 1 (DGAT1)
    Putu Yulandari - Kobe University, Japan

    Human Liver Transcriptional Mapping Via Single Cell And Single Nucleus RNA Sequencing Reveals Hepatic Parenchymal Cell Identity
    Jawairia Atif - University of Toronto, Canada

    Single-Genome Sequencing of Hepatitis C Virus in Donor-Recipient Pairs Indicates Transmission is Associated with Diversifying Selection
    Alexander Mosa, University of Toronto, Canada

    CanadaDisturbance of hepcidin-ferroportin system induced by HCV infection, leading to iron accumulation in the infected cells
    Kazuyoshi Ohta, Hamamatsu University School of Medicine, Japan

    15:30 -16:15 |Poster Tour B: Animal models, Innate Immunity, Tools
    Co-chairs: Alexander Ploss & Minkyung Yi

    Investigating Phylogenetic Dynamics of Hepatitis C Virus in the UK Population using Next Generation Sequencing
    Carol Leitch, MRC-University of Glasgow Centre for Virus Research, United Kingdom

    New murine models to study Pegivirus infection and immunopathogenesis
    Satyapramod Murthy, Nationwide Children's Hospital, United States

    Intrahost analysis of hepaciviral glycoprotein evolution reveals signatures associated with persistence and clearance
    Andre Goemer, Ruhr University Bochum, Germany

    Zika virus modulates mitochondria oxidative respiration and alters endoplasmic reticulum-mitochondria contacts in favor of viral replication
    Wesley Freppel, Institut National de la Recherche Scientifique, Canada

    16:15 -16:45 |Poster Session Continued

  • 16:45 17:30


  • 17:30 19:00

    Session 6: Viral Life Cycle 1 (Entry, Replication)

    Co-chairs: Heidi Drummer & Yi-Ping Li

    17:30 - 18:00 | Plenary Lecture 6: 30 Years of HCV Virology
                               Takaji Wakita - National Institute of Infectious Diseases, Tokyo, Japan

    18:00 - 18:25 | Keynote Lecture 7: The role of lipids and lipid-associated proteins in assembly of HCV and Flaviviruses
                               Takasuke Fukuhara - Osaka University, Osaka, Japan

    18:30 - 19:00 | Oral Presentations selected from Abstracts  

    18:30 - 18:45 | Hepatitis C virus enters via transcytosis and egresses through two different routes determined by Arf1-regulated lipid droplet metabolism
                               Abdullah A Awadh, Cornell University, United States

    18:45 - 19:00 | Characterization of Mouse shiftless antiviral inhibitor of ribosomal frameshifting (Shfl) as a restriction factor of HCV in mouse liver cells
                               Yudi Zhang, Twincore, Centre for Experimental and Clinical Infection Research, Germany

  • 19:15 20:00


  • 20:00 20:15

    Day Two Close